Selection and mutation at a diallelic X-linked locus.

Abstract excerpt

Equilibria and convergence of gene frequencies are studied in the case of a diallelic X-linked locus under the influence of selection and mutation. The model used is that of an infinite diploid population with nonoverlapping discrete generations and random mating. It is proved that if the mutation rates and fitnesses are constant and the mutation rates are less than one-third, then global convergence of gene...

Topics

• Alleles
• Female
• Gene Frequency
• Genetic Linkage
• Hemophilia A
• Humans
• Male
• Models, Genetic
• Models, Theoretical
• Mutation
• Selection, Genetic
• X Chromosome