Article
Combined Isothermal Titration and Differential Scanning Calorimetry Define Three-State Thermodynamics of fALS-Associated Mutant Apo SOD1 Dimers and an Increased Population of Folded Monomer.
Biochemistry - 26 Jan 2016
Broom Helen R, Vassall Kenrick A, Rumfeldt Jessica A O, Doyle Colleen M, Tong Ming Sze, Bonner Julia M, Meiering Elizabeth M
Abstract excerpt
Many proteins are naturally homooligomers, homodimers most frequently. The overall stability of oligomeric proteins may be described in terms of the stability of the constituent monomers and the stability of their association; together, these stabilities determine the populations of different monomer and associated species, which generally have different roles in the function or dysfunction of the protein. Here...
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