Article
B cell development in chromosome 22q11.2 deletion syndrome.
Clinical immunology (Orlando, Fla.) - 1 Feb 2016
Derfalvi Beata, Maurer Kelly, McDonald McGinn Donna M, Zackai Elaine, Meng Wenzhao, Luning Prak Eline T, Sullivan Kathleen E
Abstract excerpt
Chromosome 22q11.2 deletion syndrome is a common immune deficiency associated with thymic hypoplasia. Most patients did not survive until the mid-1980s and now there is a growing adult population. B cell and immunoglobulin defects have been described and appear to be increased in the adult population. We used flow cytometry, B cell stimulation and repertoire analysis to understand B cell function. B cell...
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