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Article

Lin28B and Let-7 in the Control of Sympathetic Neurogenesis and Neuroblastoma Development

16 Dec 2015

Abstract excerpt

The RNA binding protein Lin28B is expressed in developing tissues and sustains stem and progenitor cell identity as a negative regulator of the Let-7 family of microRNAs, which induces differentiation. Lin28B is activated in neuroblastoma (NB), a childhood tumor in sympathetic ganglia and adrenal medulla. Forced expression of Lin28B in embryonic mouse sympathoadrenal neuroblasts elicits postnatal NB formation....

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PMID: 26674877
DOI: 10.1523/jneurosci.2560-15.2015

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