Article
Enumeration and Molecular Characterization of Tumor Cells in Lung Cancer Patients Using a Novel In Vivo Device for Capturing Circulating Tumor Cells.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2016
Gorges Tobias M, Penkalla Nicole, Schalk Thomas, Joosse Simon A, Riethdorf Sabine, Tucholski Johannes, Lücke Klaus, Wikman Harriet, Jackson Stephen, Brychta Nora, von Ahsen Oliver, Schumann Christian, Krahn Thomas, Pantel Klaus
Abstract excerpt
PURPOSE: The use of circulating tumor cells (CTC) as "liquid biopsy" is limited by the very low yield of CTCs available for subsequent analyses. Most in vitro approaches rely on small sample volumes (5-10 mL). EXPERIMENTAL DESIGN: Here, we used a novel approach, the GILUPI CellCollector, which enables an in vivo isolation of CTCs from peripheral blood. In total, 50 lung cancer patients were screened in two...
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