Article
Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy.
Gene - 15 Feb 2016
Bottillo Irene, D'Angelantonio Daniela, Caputo Viviana, Paiardini Alessandro, Lipari Martina, De Bernardo Carmelilia, Giannarelli Diana, Pizzuti Antonio, Majore Silvia, Castori Marco, Zachara Elisabetta, Re Federica, Grammatico Paola
Abstract excerpt
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common genetic heart disorder characterized by unexplained left ventricle hypertrophy associated with non-dilated ventricular chambers. Several genes encoding heart sarcomeric proteins have been associated to HCM, but a small proportion of HCM patients harbor alterations in other non-sarcomeric loci. The variable expression of HCM seems influenced by genetic...
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