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Article

Calcium Electroporation: Evidence for Differential Effects in Normal and Malignant Cell Lines, Evaluated in a 3D Spheroid Model

3 Dec 2015

Abstract excerpt

BACKGROUND: Calcium electroporation describes the use of high voltage electric pulses to introduce supraphysiological calcium concentrations into cells. This promising method is currently in clinical trial as an anti-cancer treatment. One very important issue is the relation between tumor cell kill efficacy-and normal cell sensitivity. METHODS: Using a 3D spheroid cell culture model we have tested the effect of...

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PMID: 26633834
DOI: 10.1371/journal.pone.0144028

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