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Article

Wham: Identifying Structural Variants of Biological Consequence.

PLoS computational biology - 1 Dec 2015

Kronenberg Zev N, Osborne Edward J, Cone Kelsey R, Kennedy Brett J, Domyan Eric T, Shapiro Michael D, Elde Nels C, Yandell Mark

Abstract excerpt

Existing methods for identifying structural variants (SVs) from short read datasets are inaccurate. This complicates disease-gene identification and efforts to understand the consequences of genetic variation. In response, we have created Wham (Whole-genome Alignment Metrics) to provide a single, integrated framework for both structural variant calling and association testing, thereby bypassing many of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26625158
DOI: 10.1371/journal.pcbi.1004572
PMCID: PMC4666669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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