Article
Association mapping reveals the role of purifying selection in the maintenance of genomic variation in gene expression.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 2015
Josephs Emily B, Lee Young Wha, Stinchcombe John R, Wright Stephen I
Abstract excerpt
The evolutionary forces that maintain genetic variation in quantitative traits within populations remain poorly understood. One hypothesis suggests that variation is under purifying selection, resulting in an excess of low-frequency variants and a negative correlation between minor allele frequency and selection coefficients. Here, we test these predictions using the genetic loci associated with total expression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.