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The Chromosome-Encoded Hypothetical Protein TC0668 Is an Upper Genital Tract Pathogenicity Factor of Chlamydia muridarum.

Infection and immunity - 1 Feb 2016

Conrad Turner Allen, Gong Siqi, Yang Zhangsheng, Matulich Patrick, Keck Jonathon, Beltrami Noah, Chen Chaoqun, Zhou Zhou, Dai Jin, Zhong Guangming

Abstract excerpt

We previously associated a missense mutation of the tc0668 gene of serial in vitro-passaged Chlamydia muridarum, a murine model of human urogenital C. trachomatis, with severely attenuated disease development in the upper genital tract of female mice. Since these mutants also contained a TC0237 Q117E missense mutation that enhances their in vitro infectivity, an effort was made here to isolate and characterize a...

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Identifiers

PMID: 26597987
DOI: 10.1128/IAI.01171-15
PMCID: PMC4730586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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