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Article

Sofosbuvir plus ledipasvir in combination for the treatment of hepatitis C infection.

Expert review of gastroenterology & hepatology - 1 Jan 2015

Bourlière Marc, Adhoute Xavier, Ansaldi Christelle, Oules Valérie, Benali Souad, Portal Isabelle, Castellani Paul, Halfon Philippe

Abstract excerpt

Sofsobuvir is the first-in-class NS5B nucleotide inhibitor to be launched as a treatment for the hepatitis C virus (HCV). Its viral potency, pan genotypic activity and high barrier to resistance make it the ideal candidate to become a backbone for several IFN-free regimens. Ledipasvir is a NS5A inhibitor with multi genotypic activity but modest barrier to resistance. The once-daily fixed-dose combination of...

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Source

Identifiers

PMID: 26595560
DOI: 10.1586/17474124.2015.1111757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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