[KIL-d] Protein Element Confers Antiviral Activity via Catastrophic Viral Mutagenesis.

Abstract excerpt

Eukaryotic cells are targeted by pathogenic viruses and have developed cell defense mechanisms against viral infection. In yeast, the cellular extrachromosomal genetic element [KIL-d] alters killer activity of M double-stranded RNA killer virus and confers cell resistance against the killer virus. However, its underlying mechanism and the molecular nature of [KIL-d] are unknown. Here, we demonstrate that [KIL-d]...

Topics

• Antiviral Agents
• Fungal Proteins
• Gene Expression Regulation, Viral
• High-Throughput Nucleotide Sequencing
• Mutation
• RNA, Double-Stranded
• RNA, Viral
• Sequence Analysis, DNA
• Viral Proteins
• Virus Replication