Article
Impact of QTL minor allele frequency on genomic evaluation using real genotype data and simulated phenotypes in Japanese Black cattle.
BMC genetics - 19 Nov 2015
Uemoto Yoshinobu, Sasaki Shinji, Kojima Takatoshi, Sugimoto Yoshikazu, Watanabe Toshio
Abstract excerpt
BACKGROUND: Genetic variance that is not captured by single nucleotide polymorphisms (SNPs) is due to imperfect linkage disequilibrium (LD) between SNPs and quantitative trait loci (QTLs), and the extent of LD between SNPs and QTLs depends on different minor allele frequencies (MAF) between them. To evaluate the impact of MAF of QTLs on genomic evaluation, we performed a simulation study using real cattle...
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