Article
Direct reprogramming of human fibroblasts into sweat gland-like cells.
Cell cycle (Georgetown, Tex.) - 1 Jan 2015
Zhao Zhiliang, Xu Mengyao, Wu Meng, Ma Kui, Sun Mengli, Tian Xiaocheng, Zhang Cuiping, Fu Xiaobing
Abstract excerpt
The skin of patients with an extensive deep burn injury is repaired by a process that leaves a hypertrophic scar without sweat glands and therefore loses the function of perspiration. The aim of this study was to identify whether the key factors related to sweat gland development could directly reprogram fibroblasts into sweat gland-like cells. After introducing the NF-κB and Lef-1 genes into fibroblasts, we...
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