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Article

FGF7 and FGF10 Promote Fate Transition of Human Epidermal Cell-derived Organoids to an Eccrine Gland Phenotype.

International journal of biological sciences - 1 Jan 2024

Zhao Junhong, Zhang Lei, Zhang Yonghong, Cao Manxiu, Wang Cangyu, Hu Anqi, Cao Leilei, Luo Qizhi, You Zhen, Ma Xueping, Gong Liang, Zhang Cuiping, Li Haihong

Abstract excerpt

Rationale: Reconstruction of hair follicles (HFs) and eccrine sweat glands (ESGs) is essential for functional skin regeneration. In skin reconstruction research, we found that foreskin-derived epidermal cells reconstructed HF organoids unidirectionally, but not ESG organoids. Methods: To investigate key genes and pathways influencing the fate of ESG and HF, a transcriptome profiling of ESG placode-containing skin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39247826
DOI: 10.7150/ijbs.97422
PMCID: PMC11379064

Genes

FGF7
FGF10
FGFR1
FGFR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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