Article
Reassessing the Evolutionary History of the 17q21 Inversion Polymorphism.
Genome biology and evolution - 11 Nov 2015
Alves Joao M, Lima Ana C, Pais Isa A, Amir Nadir, Celestino Ricardo, Piras Giovanna, Monne Maria, Comas David, Heutink Peter, Chikhi Lounès, Amorim António, Lopes Alexandra M
Abstract excerpt
A polymorphic inversion that lies on chromosome 17q21 comprises two major haplotype families (H1 and H2) that not only differ in orientation but also in copy-number. Although the processes driving the spread of the inversion-associated lineage (H2) in humans remain unclear, a selective advantage has been proposed for one of its subtypes. Here, we genotyped a large panel of individuals from previously overlooked...
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