Article
Argonaute 2 and nasopharyngeal carcinoma: a genetic association study and functional analysis.
BMC cancer - 6 Nov 2015
Li Peiyao, Meng Jinfeng, Zhai Yun, Zhang Hongxing, Yu Lixia, Wang Zhifu, Zhang Xiaoai, Cao Pengbo, Chen Xi, Han Yuqing, Zhang Yang, Chen Huipeng, Ling Yan, Li Yuxia, Cui Ying, Bei Jin-Xin, Zeng Yi-Xin, He Fuchu, Zhou Gangqiao
Abstract excerpt
BACKGROUND: Argonaute 2 (AGO2), a central component of RNA-induced silencing complex, plays critical roles in cancer. We examined whether the single nucleotide polymorphisms (SNPs) of AGO2 were related to the risk of nasopharyngeal carcinoma (NPC). METHODS: Twenty-five tag SNPs within AGO2 were genotyped in Guangxi population consisting of 855 NPC patients and 1036 controls. The SNPs significantly associated with...
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