Article
Associations of Genetically Determined Continental Ancestry With CD4+ Count and Plasma HIV-1 RNA Beyond Self-Reported Race and Ethnicity.
Journal of acquired immune deficiency syndromes (1999) - 15 Apr 2016
Brummel Sean S, Singh Kumud K, Maihofer Adam X, Farhad Mona, Qin Min, Fenton Terry, Nievergelt Caroline M, Spector Stephen A
Abstract excerpt
BACKGROUND: Ancestry informative markers (AIMs) measure genetic admixtures within an individual beyond self-reported racial/ethnic (SRR) groups. Here, we used genetically determined ancestry (GDA) across SRR groups and examine associations between GDA and HIV-1 RNA and CD4 counts in HIV-positive children in the United States. METHODS: Forty-one AIMs, developed to distinguish 7 continental regions, were detected...
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