Understanding the role of hyperdiploidy in myeloma prognosis: which trisomies really matter?

doi:10.1182/blood-2015-06-650242

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Understanding the role of hyperdiploidy in myeloma prognosis: which trisomies really matter?

Blood - 17 Dec 2015

Chretien Marie-Lorraine, Corre Jill, Lauwers-Cances Valerie, Magrangeas Florence, Cleynen Alice, Yon Edwige, Hulin Cyrille, Leleu Xavier, Orsini-Piocelle Frederique, Blade Jean-Sebastien, Sohn Claudine, Karlin Lionel, Delbrel Xavier, Hebraud Benjamin, Roussel Murielle, Marit Gerald, Garderet Laurent, Mohty Mohamad, Rodon Philippe, Voillat Laurent, Royer Bruno, Jaccard Arnaud, Belhadj Karim, Fontan Jean, Caillot Denis, Stoppa Anne-Marie, Attal Michel, Facon Thierry, Moreau Philippe, Minvielle Stephane, Avet-Loiseau Hervé

Abstract excerpt

The prognosis of multiple myeloma is mainly dependent upon chromosomal changes. The 2 major abnormalities driving poor outcome are del(17p) and t(4;14). However, the outcome of these high-risk patients is not absolutely uniform, with some patients presenting long survival. We hypothesized that these better outcomes might be related to concomitant "good-risk" chromosomal changes exploring hyperdiploidy. We...

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Identifiers

PMID: 26516228
DOI: 10.1182/blood-2015-06-650242
PMCID: PMC4683332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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