Article
Allelic variation contributes to bacterial host specificity.
Nature communications - 30 Oct 2015
Yue Min, Han Xiangan, De Masi Leon, Zhu Chunhong, Ma Xun, Zhang Junjie, Wu Renwei, Schmieder Robert, Kaushik Radhey S, Fraser George P, Zhao Shaohua, McDermott Patrick F, Weill François-Xavier, Mainil Jacques G, Arze Cesar, Fricke W Florian, Edwards Robert A, Brisson Dustin, Zhang Nancy R, Rankin Shelley C, Schifferli Dieter M
Abstract excerpt
Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gene gain or loss, the role of pathoadaptive nonsynonymous single-nucleotide polymorphisms (nsSNPs) has not been systematically evaluated. Here, our genome-wide analysis...
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