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Article

A Double Heterozygous Mutation of TNNI3 Causes Hypertrophic Cardiomyopathy in a Han Chinese Family.

Cardiology - 1 Jan 2016

Zheng Hua, Huang Huajie, Ji Zhisong, Yang Qi, Yu Qiuxia, Shen Fan, Liu Cuixian, Xiong Fu

Abstract excerpt

OBJECTIVES: To investigate the variations in the TNNI3 gene in a Chinese Han family affected by hypertrophic cardiomyopathy (HCM) and the potential molecular mechanism linking these mutations with disease. METHODS: Peripheral venous blood was acquired from family members, and TNNI3 mutations were identified by DNA sequencing. The pathophysiology of TNNI3 mutations was investigated using bioinformatics,...

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Source

Identifiers

PMID: 26506446
DOI: 10.1159/000440877

Genes

TNNI3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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