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Article

Effect of 22q11.2 deletion on bleeding and transfusion utilization in children with congenital heart disease undergoing cardiac surgery.

Pediatric research - 1 Feb 2016

Brenner Michelle K, Clarke Shanelle, Mahnke Donna K, Simpson Pippa, Bercovitz Rachel S, Tomita-Mitchell Aoy, Mitchell Michael E, Newman Debra K

Abstract excerpt

BACKGROUND: Postsurgical bleeding causes significant morbidity and mortality in children undergoing surgery for congenital heart defects (CHD). 22q11.2 deletion syndrome (DS) is the second most common genetic risk factor for CHD. The deleted segment of chromosome 22q11.2 encompasses the gene encoding glycoprotein (GP) Ibβ, which is required for expression of the GPIb-V-IX complex on the platelet surface, where it...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 22

Share to DiGeorge Syndrome

Share to Erythrocyte Transfusion

Share to Heart Defects, Congenital

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Identifiers

PMID: 26492284
DOI: 10.1038/pr.2015.216
PMCID: PMC5114022

Genes

VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of 22q11.2 deletion on bleeding and transfusion utilization in children with congenital heart disease undergoing cardiac surgery.PMID 26492284Read ↗

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