Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Nuclear Factor (Erythroid-derived 2)-like 2 and Proteasome Maturation Protein Axis Mediate Bortezomib Resistance in Multiple Myeloma

20 Oct 2015

Abstract excerpt

Resistance to the proteasome inhibitor bortezomib is an emerging clinical problem whose mechanisms have not been fully elucidated. We considered the possibility that this could be associated with enhanced proteasome activity in part through the action of the proteasome maturation protein (POMP). Bortezomib-resistant myeloma models were used to examine the correlation between POMP expression and bortezomib...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multiple Myeloma Research and Treatments
Share to Protein Degradation and Inhibitors
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26483548
DOI: 10.1074/jbc.m115.664953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Nuclear Factor (Erythroid-derived 2)-like 2 and Proteasome Maturation Protein Axis Mediate Bortezomib Resistance in Multiple MyelomaPMID 26483548Read ↗

Activating KRAS, NRAS, and BRAF mutants enhance proteasome capacity and reduce endoplasmic reticulum stress in multiple myeloma.Semantic proximity Read ↗

NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple MyelomaSemantic proximity Read ↗

Endoplasmic reticulum stress in the development of multiple myeloma and drug resistanceSemantic proximity Read ↗

Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myelomaSemantic proximity Read ↗

KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cellsSemantic proximity Read ↗

High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myelomaSemantic proximity Read ↗

Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress.Semantic proximity Read ↗

Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple MyelomaSemantic proximity Read ↗

The Transcription Axes ERK-Elk1, JNK-cJun, and JAK-STAT Promote Autophagy Activation and Proteasome Inhibitor Resistance in Prostate Cancer CellsSemantic proximity Read ↗

Profiling Bortezomib Resistance Identifies Secondary Therapies in a Mouse Myeloma ModelSemantic proximity Read ↗

Molecular Mechanisms of Bortezomib Resistant Adenocarcinoma CellsSemantic proximity Read ↗

Monitoring a Nuclear Factor-κB Signature of Drug Resistance in Multiple MyelomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.