Article
Integrating mRNA and Protein Sequencing Enables the Detection and Quantitative Profiling of Natural Protein Sequence Variants of Populus trichocarpa.
Journal of proteome research - 4 Dec 2015
Abraham Paul E, Wang Xiaojing, Ranjan Priya, Nookaew Intawat, Zhang Bing, Tuskan Gerald A, Hettich Robert L
Abstract excerpt
Next-generation sequencing has transformed the ability to link genotypes to phenotypes and facilitates the dissection of genetic contribution to complex traits. However, it is challenging to link genetic variants with the perturbed functional effects on proteins encoded by such genes. Here we show how RNA sequencing can be exploited to construct genotype-specific protein sequence databases to assess natural...
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