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Article

Sequence Variation in Amplification Target Genes and Standards Influences Interlaboratory Comparison of BK Virus DNA Load Measurement.

Journal of clinical microbiology - 1 Dec 2015

Solis Morgane, Meddeb Mariam, Sueur Charlotte, Domingo-Calap Pilar, Soulier Eric, Chabaud Angeline, Perrin Peggy, Moulin Bruno, Bahram Seiamak, Stoll-Keller Françoise, Caillard Sophie, Barth Heidi, Fafi-Kremer Samira

Abstract excerpt

International guidelines define a BK virus (BKV) load of ≥4 log10 copies/ml as presumptive of BKV-associated nephropathy (BKVN) and a cutoff for therapeutic intervention. To investigate whether BKV DNA loads (BKVL) are comparable between laboratories, 2 panels of 15 and 8 clinical specimens (urine, whole blood, and plasma) harboring different BKV genotypes were distributed to 20 and 27 French hospital centers in...

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Identifiers

PMID: 26468499
DOI: 10.1128/JCM.02145-15
PMCID: PMC4652096

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