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Article

Mechanisms of Virologic Failure with Direct-Acting Antivirals in Hepatitis C and Strategies for Retreatment.

Clinics in liver disease - 1 Nov 2015

Costilla Vanessa, Mathur Neha, Gutierrez Julio A

Abstract excerpt

The current standard of care for hepatitis C therapy is the combination of direct-acting antiviral (DAA) agents. These orally administered medications target the viral proteins and halt the hepatitis C virus lifecycle. Despite high cure rates with these novel drugs, virologic failure with DAAs are of mounting concern as real-world sustained virologic response 12 rates seem lower than expected. The mechanisms of...

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Identifiers

PMID: 26466653
DOI: 10.1016/j.cld.2015.06.005

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