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Article

α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth

13 Oct 2015

Abstract excerpt

Spinal muscular atrophy (SMA), a heritable neurodegenerative disease, results from insufficient levels of the survival motor neuron (SMN) protein. α-COP binds to SMN, linking the COPI vesicular transport pathway to SMA. Reduced levels of α-COP restricted development of neuronal processes in NSC-34 cells and primary cortical neurons. Remarkably, heterologous expression of human α-COP restored normal neurite length...

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PMID: 26464491
DOI: 10.1093/hmg/ddv428

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