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Article

Relative contribution of biological variation and technical variables to zone diameter variations of disc diffusion susceptibility testing

12 Oct 2015

Abstract excerpt

OBJECTIVES: Disc diffusion is still largely based on manual procedures. Technical variations originate from inoculum preparation, variations in materials, individual operator plate streaking and reading accuracy. Resulting measurement imprecision contributes to categorization errors. Biological variation resembles the natural fluctuation of a measured parameter such as antibiotic susceptibility around a mean...

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PMID: 26462987
DOI: 10.1093/jac/dkv309

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