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Article

Three-Dimensional Vascular Network Assembly From Diabetic Patient-Derived Induced Pluripotent Stem Cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2015

Chan Xin Yi, Black Rebecca, Dickerman Kayla, Federico Joseph, Lévesque Mathieu, Mumm Jeff, Gerecht Sharon

Abstract excerpt

OBJECTIVE: In diabetics, hyperglycemia results in deficient endothelial progenitors and cells, leading to cardiovascular complications. We aim to engineer 3-dimensional (3D) vascular networks in synthetic hydrogels from type 1 diabetes mellitus (T1D) patient-derived human-induced pluripotent stem cells (hiPSCs), to serve as a transformative autologous vascular therapy for diabetic patients. APPROACH AND RESULTS:...

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Identifiers

PMID: 26449749
DOI: 10.1161/ATVBAHA.115.306362
PMCID: PMC4603427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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