Article
Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.
Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2012
Feldman Chris R, Brodie Edmund D, Brodie Edmund D, Pfrender Michael E
Abstract excerpt
Natural selection often produces convergent changes in unrelated lineages, but the degree to which such adaptations occur via predictable genetic paths is unknown. If only a limited subset of possible mutations is fixed in independent lineages, then it is clear that constraint in the production or function of molecular variants is an important determinant of adaptation. We demonstrate remarkably constrained...
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