Article
Construction of recombinant adenovirus containing picorna-viral 2A-peptide sequence for the co-expression of neuro-protective growth factors in human umbilical cord blood cells.
Spinal cord - 1 Jun 2016
Garanina E E, Mukhamedshina Y O, Salafutdinov I I, Kiyasov A P, Lima L M, Reis H J, Palotás A, Islamov R R, Rizvanov A A
Abstract excerpt
STUDY DESIGN: Experimental study. OBJECTIVE: Several neuro-degenerative disorders such as Alzheimer's dementia, Parkinson's disease and amyotrophic lateral sclerosis (ALS) are associated with genetic mutations, and replacing or disrupting defective sequences might offer therapeutic benefits. Single gene delivery has so far failed to achieve significant clinical improvements in humans, leading to the advent of...
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