Acquired and congenital fast albumin bands; insights from electrospray TOF analysis of whole plasma into drug binding and albumin recycling.

Abstract excerpt

OBJECTIVES: To define the underlying cause of unusual fast albumin bands detected on plasma protein electrophoresis of two patients. METHOD: Plasma was examined by electrospray time-of-flight mass spectrometry (TOF MS) to assess the possibility of congenital or acquired structural modifications. RESULTS: In one patient whole protein MS indicated a drop of 486Da in the mass of 5.1% of the albumin molecules. This...

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