Article
Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland.
Histopathology - 1 Jun 2016
Piscuoglio Salvatore, Fusco Nicola, Ng Charlotte K Y, Martelotto Luciano G, da Cruz Paula Arnaud, Katabi Nora, Rubin Brian P, Skálová Alena, Weinreb Ilan, Weigelt Britta, Reis-Filho Jorge S
Abstract excerpt
AIMS: Polymorphous low-grade adenocarcinoma (PLGA) is the second most common intra-oral salivary gland malignancy. The vast majority of PLGAs harbour a PRKD1 E710D hot-spot somatic mutation or somatic rearrangements of PRKD1, PRKD2 or PRKD3. Given the kinase domain homology among PRKD1, PRKD2 and PRKD3, we sought to define whether PLGAs lacking PRKD1 somatic mutations or PRKD gene family rearrangements would be...
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