Article
NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease.
The American journal of surgical pathology - 1 Feb 2016
Martinez Daniel, Navarro Alba, Martinez-Trillos Alejandra, Molina-Urra Ricardo, Gonzalez-Farre Blanca, Salaverria Itziar, Nadeu Ferran, Enjuanes Anna, Clot Guillem, Costa Dolors, Carrio Ana, Villamor Neus, Colomer Dolors, Martinez Antonio, Bens Susanne, Siebert Reiner, Wotherspoon Andrew, Beà Sílvia, Matutes Estella, Campo Elias
Abstract excerpt
Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is considered an indolent neoplasm and its pathogenesis is not well known. We investigated the molecular characteristics of 19 SDRPL patients, 5 of them with progressive disease. IGHV genes were mutated in 9/13 (69%). Cytogenetic and molecular studies identified complex karyotypes in 2 cases, and IGH rearrangements in 3, with PAX5 and potentially TCL1 as...
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