The Hematopoietic Syndrome of the Acute Radiation Syndrome in Rhesus Macaques

Abstract excerpt

Well characterized animal models that mimic the human response to potentially lethal doses of radiation are required to assess the efficacy of medical countermeasures under the criteria of the U.S. Food and Drug Administration "animal rule." Development of a model requires the determination of the radiation dose response relationship and time course of mortality and morbidity across the hematopoietic acute...

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