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Serum miRNA-based signature indicates radiation exposure and dose in humans: A multicenter diagnostic biomarker study

8 Jun 2023

Abstract excerpt

PURPOSE: Mouse and non-human primate models showed that serum miRNAs may be used to predict the biological impact of radiation doses. We hypothesized that these results can be translated to humans treated with total body irradiation (TBI), and that miRNAs may be used as clinically feasible biodosimeters. METHODS: To test this hypothesis, serial serum samples were obtained from 25 patients (pediatric and adults)...

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PMID: 37301262
DOI: 10.1016/j.radonc.2023.109731

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