Predictors of survival and effect of short (40 Gy) or standard-course (60 Gy) irradiation plus concomitant temozolomide in elderly patients with glioblastoma: a multicenter retrospective study of AINO (Italian Association of Neuro-Oncology).

doi:10.1007/s11060-015-1923-x

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Article

Predictors of survival and effect of short (40 Gy) or standard-course (60 Gy) irradiation plus concomitant temozolomide in elderly patients with glioblastoma: a multicenter retrospective study of AINO (Italian Association of Neuro-Oncology).

Journal of neuro-oncology - 1 Nov 2015

Lombardi Giuseppe, Pace Andrea, Pasqualetti Francesco, Rizzato Simona, Faedi Marina, Anghileri Elena, Nicolotto Elisa, Bazzoli Elena, Bellu Luisa, Villani Veronica, Fabi Alessandra, Ferrazza Patrizia, Gurrieri Lorena, Dall'Agata Monia, Eoli Marica, Della Puppa Alessandro, Pambuku Ardi, D'Avella Domenico, Berti Franco, Rudà Roberta, Zagonel Vittorina

Abstract excerpt

The efficacy of temozolomide (TMZ) plus radiation therapy (RT) in elderly patients with glioblastoma is unclear. We performed a large multicenter retrospective study to analyze prognostic factors and clinical outcome in these patients. Inclusion criteria were age ≥65 years, newly histologically confirmed glioblastoma, ECOG PS 0-2, adjuvant treatment with RT plus TMZ. We enrolled 237 patients; the average age was...

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PMID: 26423801
DOI: 10.1007/s11060-015-1923-x

Genes

MGMT
IDH1

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