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Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function

25 Sept 2015

Abstract excerpt

Membrane proteins are crucial to heart function and development. Here we combine cationic silica-bead coating with shotgun proteomics to enrich for and identify plasma membrane-associated proteins from primary mouse neonatal and human fetal ventricular cardiomyocytes. We identify Tmem65 as a cardiac-enriched, intercalated disc protein that increases during development in both mouse and human hearts. Functional...

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PMID: 26403541
DOI: 10.1038/ncomms9391

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