Article
Outcome of relapsing Clostridium difficile infections do not correlate with virulence-, spore- and vegetative cell-associated phenotypes.
Anaerobe - 1 Dec 2015
Plaza-Garrido Ángela, Miranda-Cárdenas Camila, Castro-Córdova Pablo, Olguín-Araneda Valeria, Cofré-Araneda Glenda, Hernández-Rocha Cristian, Carman Robert, Ibáñez Patricio, Fawley Warren N, Wilcox Mark H, Gil Fernando, Calderón Iván L, Fuentes Juan A, Guzmán-Durán Ana María, Alvarez-Lobos Manuel, Paredes-Sabja Daniel
Abstract excerpt
One of the main clinical challenges of Clostridium difficile infections (CDI) is the high rate of relapse episodes. The main determinants involved in relapse of CDI include the presence of antibiotic-resistant C. difficile spores in the colonic environment and a permanent state of dysbiosis of the microbiota caused by antibiotic therapy. A possible scenario is that phenotypes related to the persistence of C....
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