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Article

Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing

24 Sept 2015

Abstract excerpt

UNLABELLED: Precise delineation of the specific genes and pathways altered with aging and estrogen (E) therapy may lead to new skeletal biomarkers and the development of novel bone therapeutics. Previous human bone studies, however, have been limited by only examining pre-specified genes and pathways. High-throughput RNA sequencing (RNAseq), on the other hand, offers an unbiased approach to examine the entire...

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PMID: 26402159
DOI: 10.1371/journal.pone.0138347

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