Article
Promoter methylation is not associated with FLCN irregulation in lung cyst lesions of primary spontaneous pneumothorax.
Molecular medicine reports - 1 Nov 2015
Ding Yibing, Zou Wei, Zhu Chengchu, Min Haiyan, Ma Dehua, Chen Baofu, Ye Minhua, Pan Yanqing, Cao Lei, Wan Yueming, Zhu Qiuxiang, Xia Haizhen, Zhang Wenwen, Feng Ying, Gao Qian, Yi Long
Abstract excerpt
Germline mutations in FLCN are responsible for ~10% of patients with primary spontaneous pneumothorax (PSP), characterized by multiple lung cysts in the middle/lower lobes and recurrent pneumothorax. These clinical features are also observed in a substantial portion of patients with sporadic PSP exhibiting no FLCN coding mutations. To assess the potential underlying mechanisms, 71 patients with PSP were selected,...
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