Article
The Widespread Multidrug-Resistant Serotype O12 Pseudomonas aeruginosa Clone Emerged through Concomitant Horizontal Transfer of Serotype Antigen and Antibiotic Resistance Gene Clusters.
mBio - 22 Sept 2015
Thrane Sandra Wingaard, Taylor Véronique L, Freschi Luca, Kukavica-Ibrulj Irena, Boyle Brian, Laroche Jérôme, Pirnay Jean-Paul, Lévesque Roger C, Lam Joseph S, Jelsbak Lars
Abstract excerpt
UNLABELLED: The O-specific antigen (OSA) in Pseudomonas aeruginosa lipopolysaccharide is highly varied by sugar identity, side chains, and bond between O-repeats. These differences classified P. aeruginosa into 20 distinct serotypes. In the past few decades, O12 has emerged as the predominant serotype in clinical settings and outbreaks. These serotype O12 isolates exhibit high levels of resistance to various...
Topics
- Drug Resistance, Bacterial
- Evolution, Molecular
- Gene Transfer, Horizontal
- Genomic Islands
- Genotype
- Multigene Family
- O Antigens
- Pseudomonas aeruginosa
- Recombination, Genetic
- Serogroup