Article
Construction of high-quality recombination maps with low-coverage genomic sequencing for joint linkage analysis in maize.
BMC biology - 21 Sept 2015
Li Chunhui, Li Yongxiang, Bradbury Peter J, Wu Xun, Shi Yunsu, Song Yanchun, Zhang Dengfeng, Rodgers-Melnick Eli, Buckler Edward S, Zhang Zhiwu, Li Yu, Wang Tianyu
Abstract excerpt
BACKGROUND: A genome-wide association study (GWAS) is the foremost strategy used for finding genes that control human diseases and agriculturally important traits, but it often reports false positives. In contrast, its complementary method, linkage analysis, provides direct genetic confirmation, but with limited resolution. A joint approach, using multiple linkage populations, dramatically improves resolution and...
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