Genetic mutations in African patients with atrial fibrillation: Rationale and design of the Study of Genetics of Atrial Fibrillation in an African Population (SIGNAL).

doi:10.1016/j.ahj.2015.06.008

Article

Genetic mutations in African patients with atrial fibrillation: Rationale and design of the Study of Genetics of Atrial Fibrillation in an African Population (SIGNAL).

American heart journal - 1 Sept 2015

Bloomfield Gerald S, Temu Tecla M, Akwanalo Constantine O, Chen Peng-Sheng, Emonyi Wilfred, Heckbert Susan R, Koech Myra M, Manji Imran, Shen Changyu, Vatta Matteo, Velazquez Eric J, Wessel Jennifer, Kimaiyo Sylvester, Inui Thomas S

Abstract excerpt

BACKGROUND: There is an urgent need to understand genetic associations with atrial fibrillation in ethnically diverse populations. There are no such data from sub-Saharan Africa, despite the fact that atrial fibrillation is one of the fastest growing diseases. Moreover, patients with valvular heart disease are underrepresented in studies of the genetics of atrial fibrillation. METHODS: We designed a case-control...

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Genetic mutations in African patients with atrial fibrillation: Rationale and design of the Study of Genetics of Atrial Fibrillation in an African Population (SIGNAL).

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