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Article

CDKN3 mRNA as a Biomarker for Survival and Therapeutic Target in Cervical Cancer

15 Sept 2015

Abstract excerpt

The cyclin-dependent kinase inhibitor 3 (CDKN3) gene, involved in mitosis, is upregulated in cervical cancer (CC). We investigated CDKN3 mRNA as a survival biomarker and potential therapeutic target for CC. CDKN3 mRNA was measured in 134 CC and 25 controls by quantitative PCR. A 5-year survival study was conducted in 121 of these CC patients. Furthermore, CDKN3-specific siRNAs were used to investigate whether...

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PMID: 26372210
DOI: 10.1371/journal.pone.0137397

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