Article
On the Estimation of Heritability with Family-Based and Population-Based Samples.
BioMed research international - 1 Jan 2015
Kim Youngdoe, Lee Young, Lee Sungyoung, Kim Nam Hee, Lim Jeongmin, Kim Young Jin, Oh Ji Hee, Min Haesook, Lee Meehee, Seo Hyeon-Jeong, Lee So-Hyun, Sung Joohon, Cho Nam H, Kim Bong-Jo, Han Bok-Ghee, Elston Robert C, Won Sungho, Lee Juyoung
Abstract excerpt
For a family-based sample, the phenotypic variance-covariance matrix can be parameterized to include the variance of a polygenic effect that has then been estimated using a variance component analysis. However, with the advent of large-scale genomic data, the genetic relationship matrix (GRM) can be estimated and can be utilized to parameterize the variance of a polygenic effect for population-based samples....
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