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Article

Graded gene expression changes determine phenotype severity in mouse models of CRX-associated retinopathies.

Genome biology - 1 Sept 2015

Ruzycki Philip A, Tran Nicholas M, Kefalov Vladimir J, Kolesnikov Alexander V, Chen Shiming

Abstract excerpt

BACKGROUND: Mutations in the cone-rod-homeobox protein CRX are typically associated with dominant blinding retinopathies with variable age of onset and severity. Five well-characterized mouse models carrying different Crx mutations show a wide range of disease phenotypes. To determine if the phen...

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Share to Basic-Leucine Zipper Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Photoreceptor Cells, Vertebrate

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Source

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Identifiers

PMID: 26324254
DOI: 10.1186/s13059-015-0732-z
PMCID: PMC4556057

Genes

CRX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26324254-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Graded gene expression changes determine phenotype severity in mouse models of CRX-associated retinopathies.PMID 26324254Read ↗

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Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanismsSemantic proximity Read ↗

CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoidsSemantic proximity Read ↗

Mechanistically distinct mouse models for CRX-associated retinopathy.Semantic proximity Read ↗

A typology of photoreceptor gene expression patterns in the mouseSemantic proximity Read ↗

Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanismsSemantic proximity Read ↗

CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sitesSemantic proximity Read ↗

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Mutational scanning of <i>CRX</i> classifies clinical variants and reveals biochemical properties of the transcriptional effector domainSemantic proximity Read ↗

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