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Article

Silica bioreplication preserves three-dimensional spheroid structures of human pluripotent stem cells and HepG2 cells.

Scientific reports - 1 Sept 2015

Lou Yan-Ru, Kanninen Liisa, Kaehr Bryan, Townson Jason L, Niklander Johanna, Harjumäki Riina, Jeffrey Brinker C, Yliperttula Marjo

Abstract excerpt

Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, they are increasingly employed as models for cancer and drug research, as well as tissue engineering. It has proven challenging to stabilize spheroid architectures for detailed morphological examination. Here we overcome this issue using a...

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Identifiers

PMID: 26323570
DOI: 10.1038/srep13635
PMCID: PMC4555166

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