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Systems biology-based discovery of a potential Atg4B agonist (Flubendazole) that induces autophagy in breast cancer

12 Aug 2015

Abstract excerpt

The aim of this study was to explore the autophagy-related protein 4B(ATG4B) and its targeted candidate agonist in triple-negative breast cancer (TNBC) therapy. In this study, the identification of Atg4B as a novel breast cancer target for screening candidate small molecular agonists was performed by phylogenetic analysis, network construction, molecular modelling, molecular docking and molecular dynamics (MD)...

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PMID: 26299935
DOI: 10.1039/c5mb00466g

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