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Article

Phenotypic Screening for Friedreich Ataxia Using Random shRNA Selection.

Journal of biomolecular screening - 1 Oct 2015

Cotticelli M Grazia, Acquaviva Fabio, Xia Shujuan, Kaur Avinash, Wang Yongping, Wilson Robert B

Abstract excerpt

Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardio-degenerative disorder for which there are no proven effective treatments. FRDA is caused by decreased expression and/or function of the protein frataxin. Frataxin chaperones iron in the mitochondrial matrix and regulates the iron-sulfur cluster (ISC) assembly complex. ISCs are prosthetic groups critical for the function of the Krebs cycle and...

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Identifiers

PMID: 26286937
DOI: 10.1177/1087057115600433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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